Clenbuterol hydrochloride(Clenbuterol, Clenbunex) is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. Of particular interest is the fact that this drug has' little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows clenbuterol hydrochloride to reduce reversible airway obstruction (an effect of beta-2 stimulation) with much less cardiovascular side effects compared to non-selective beta agonists. Clinical studies with this drug show it is extremely effective as a bronchodilator, with a low level of user complaints and high patient compliance. Clenbuterol hydrochloride also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours long. This makes steady blood levels easy to achieve, requiring only a single or twice daily dosing schedule at most . This of course makes it much easier for the patient to use, and may tie in to its high compliance rate.
In animal studies clenbuterol hydrochloride is shown to exhibit anabolic activity ,obviously an attractive trait to a bodybuilder or athlete. This compound is additionally a known thermogenic, with beta-2 agonists like clenbuterol hydrochloride shown to directly stimulate fat cells and accelerate the breakdown of triglycerides to form free fatty acids. Its efficacy in this area makes clenbuterol hydrochloride a very popular fat loss drug among the bodybuilding community.Those interested in this drug are often hoping it will produce a little of both benefits, promoting the loss of body fat while imparting increases in strength and muscle mass.
When used for the management of asthma, the most common clinical dose for adults is 20mcg (1 tablet) twice per day. Some patients require up to 40mcg (2 tablets) twice per day. When using the drug (off-label) for physique-or performance-enhancing purposes, bodybuilders and athletes generally tailor their dosage and cycling of this product based on personal sensitivity to its benefits and side effects. To accomplish this, one often begins a cycle by taking one or two tablets per day, and gradually increasing the dosage every third day by one half to 1 tablet until a desired dosage range is established. At peak therapy some users can tolerate as many as 6-8 tablets per day (120-160mcg).
As mentioned, taking Clenbuterol quickly results in the down-regulation of the beta 2 receptors; limiting the amount of time the drug is effective.
Ketotifen, an anti-histamine used commonly to treat itchy red eyes brought on by allergies, has been shown to stop the down-regulation of the beta receptors, and is therefore of great interest to bodybuilders and athletes. A daily dose of 3mg of Ketotifen cleans the receptors, discarding the need for short Clenbuterol cycles and heightening the effect of the drug in the body.
With Ketotifen, you can limit your maximum daily dosage of Clenbuterol to 80-100mcg.