ORAL STEROIDS


Oral Steroids

In order to recap from our article about injectable steroids. We have explained that anabolic androgenic steroids are organic compounds that hold a chemical structure characterized by a particular arrangement. Every steroid compound is different based on specific structural variables.

Naturally, There are many different types of steroids, the majority of which have no muscle-building effect, strength, or athletic performance whatsoever. As a matter of fact, many of those destroy and break down muscle tissue, such as corticosteroids.
We have previously explained that the human body naturally produces different types of steroids such as Cholesterol, Cholecalciferol (Vitamin D), Estrogen, Testosterone, and Cortisol. One interesting fact is that Vitamin D is actually a steroidal molecule but contains a broken chemical ring. Even more interesting is that Cholesterol is the base steroidal compound or the precursor that the bodys cells use to synthesize all other steroids
Testosterone is the primary anabolic steroid manufactured in every human body and in most animal species. It is the male sex hormone that provides the male gender with male traits and characteristics. This hormone is responsible for controlling the maintenance of many different functions in the human body, one of which is muscle fiber growth. Another Two naturally produced anabolic steroids in humans are Dihydrotestosterone (DHT) and Nandrolone. These are the three main anabolic steroids from which all other anabolic steroids are derived.

It safe to say that all anabolic steroids in existence are basically modified forms of Testosterone, Dihydrotestosterone, or Nandrolone. These modified variants are called analogs and derivatives.
Even more, Testosterone is quite literally the original and primary hormone and which every single anabolic steroid is derived from.
Based on the aforementioned fact, we can essentially categorize anabolic androgenic steroids as:
1. Testosterone analogs and derivatives
2. Dihydrotestosterone analogs and derivatives
3. Nandrolone analogs and derivatives
 
Testosterone is transformed into Dihydrotestosterone by an enzyme called the 5-alpha reductase (5AR), and what is interesting is that Nandrolone is a byproduct of the aromatization of Testosterone into Estrogen.
Naturally theoretically, every derivative will often take on the same properties and characteristics of its parent hormone. For example, all Dihydrotestosterone (DHT) derivatives inherit its inability to convert into Estrogen because of the inability to interact with the aromatase enzyme. But this inheritance of the same traits most often exists in theory. However, in practice, the opposite may be the truth or at least a differing effect. This is because once an anabolic steroid is modified, the new analog is, in reality, a totally different hormone with unique properties and it may or may not share characteristics with its parent hormone.
We should remember as well that the main purpose behind chemically altering and modifying Testosterone is to create variants and analogs of Testosterone that could exhibit varying effects. Such modifications would allow a particular anabolic steroid analog to be more preferable to treat a certain condition or disease in medicine than Testosterone itself would be able to. The other reason is essential to minimize the undesired side effect that may or may not occur when utilizing Testosterone, by creating a milder side effect profile steroid.
Those were the medical reason for such modifications. However, when the purpose of anabolic steroids is performance and physique enhancement, the idea behind the modification and the use of different anabolic steroid types is very different and somehow clear. The first obvious reason is the discovery of an anabolic steroid analog that would exhibit a stronger anabolic effect than Testosterone, and of course with a less negative side effect profile which makes it more preferable to any athlete.
For example, Testosterone may result in water retention because of the ability to aromatize into Estrogen. Such an effect might not be a concern for a strength athlete or a powerlifter, However, this is not all beneficial for other athletes whose main goal is speed such as sprinting. Instead, a sprinter.
One more thing to be considered is that all these analogs and because of the above-mentioned modifications, all anabolic androgenic steroids differ in their ability to bind to the androgen receptor and therefore can be categorized into Class 1 and Class 2, Class 1 is the one with the strongest binding affinity to the receptor. This is where the idea of stacking stems from. When stacking or combining 2 or 3 steroids together in a cycle, the athlete is able to increase the synergistic effects between the anabolic steroids to create a highly anabolic environment or to reach a specific goal.
Another fact of extreme importance is that Testosterone is always considered the reference point when measuring any other anabolic steroid strength and effect in regards to the androgenic and anabolic abilities, much like the Celsius scale of temperature measurement where the freezing point and boiling points of water are used as the baseline measurements for temperature. Testosterones anabolic and androgenic ratings are both 100.
Based on their mode of application, there exist Two types of steroids. Oral and injectables.
 
Oral anabolic androgenic steroids are usually considered as class 2 steroids due to their poor binding affinity to the androgen receptor and therefore they are best stacked with a class 1 steroids in order to achieve the maximum desired effect. Usually, those class 1 steroids are injectables. One more reason to avoid oral only cycle is that most oral steroids are c17 alfa-alkylated or methylated AAS and therefore liver toxic and their use should be limited to no more than 6 weeks in a steroid cycle.
Oral steroids usually go through what is known as the first pass liver deactivation unless their chemical molecular structures are altered to make them harder to deactivate. When an oral AAS is taken through the mouth it enters the stomach where it is partially broken down and passed to the small intestines. The small intestines contain a group of enzymes called CYP-450s. These enzymes begin to break down the AAS further in an attempt to deactivate it. The AAS is then absorbed through intestinal mucosa cells and transferred to the liver portal vein for further deactivation. These chemicals are then conjugated with glucuronic acid and excreted in the urine. Up to 100% of the original compound can be deactivated in this process which is known as the first-pass deactivation.
 
The alteration of the parent hormone by methylation creates a heavy load upon the liver and will alter or affect enzyme and other chemical levels. This is why orals, particularly methyltestosterone and Anadrol, are so harmful if administered for prolonged periods and in high dosages. The reason that this alteration is done is that more of the AAS enters the bloodstream and remains active for a prolonged period.
 
Like their injectable cousins, oral steroids are also altered for higher or lower ratios of anabolic and androgenic effects. As an example, injectable Testosterone is highly androgenic and highly anabolic. By altering the testosterone molecule structure, nor-testosterones such as Nandrolones are created. This shifts the ratio in favor of anabolic qualities with less androgenic effects. It is true that the higher the androgenic and potential aromatization quality an AAS possesses, the higher the number of negative side effects possible. However, we should realize that this is not necessarily due to the androgenic quality itself. This is more so due to aromatization to estrogens and its effects upon HPTA function. For this reason, it would seem that a total anabolic steroid with no androgenic effects would be highly effective with an absence of possible negative side effects, Such is the case with Anavar.
 
Some of the most known and widely used oral steroids are, Dianabol (Methandrostenolone), Anadrol (Oxymetholone), Anavar (Oxandrolone), Superdrol (Methyldrostanolone), and Primobolan.
 
Again and due to its extreme importance to be understood, a note concerning all anabolic androgenic steroids in both forms, Oral or Injectables is that there is NO such a thing as Anabolic Steroids for Bulking and different ones for Cutting. This is simply a myth.
Anabolic steroids do not directly burn fat, rather they instead simply increase nutrient partitioning which is directing/shuttling ingested nutrients, vitamins, and minerals towards muscle repair and muscle growth to a large degree – so much so that fat storage is either completely avoided or dramatically reduced. Anabolic steroids do not possess any direct effects on fat metabolism that would result in dramatic changes. Anabolic steroids do interact with androgen receptors on fat tissue to initiate lipolysis (fat breakdown), but this does not occur to any significant degree.
The effect of any steroid whether it is fat burning or bulking and muscle mass gains is 100% dependent on the individuals nutrition and training. Different types of steroids merely serve to amplify the efforts and hard work that the nutrition and training aspects have properly established.